Getting rid of the spare?

Anatoray

As long as you have one or the other and know how to use it or what to do if it's not going to work out, there's no problem. Since you have the bose system, however, I am not sure how well it will work out, because the two subs sit below and above the spare. Of course, it wouldn't take long to check it out. If you're only going for weight reduction, and not trying to get some extra trunk space, it could be possible to build a little enclosure to hold the sub where it would be if the tire was in there.