need help deciding on my audio build

RonRizz

The 165k's are $600. the isc100's are $150. That's $750, not $1600++ unless you're using common core. lol. but seriously;
The 165kr are rated at 80w rms, the isc100 at 40w rms. The amp is rated at 100w rms, more than enough to drive these speakers to their potential and beyond. If the OP were interested in, say, competing in Iasca or Meca, I would recommend something else.
Costs more doesn't mean sounds better. Something I learned a looong time ago.

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P99rs Head Unit--- Amps- 2 Pioneer Prs800d --- Zapco ST1000MX---Zapco ST-4XSQ---- SI BM mk5 Subs---SI TM65v2 Midbass--- SI M3 mids--- SI M25 xbl2 tweeters ----- 2016 MECA street class 3rd place at world finals