Ideally, you'd probably want to run new speaker wire but it's not absolutely required. Fatter wires generally equal a little bit better levels but you're not likely to notice a difference if you aren't an audiophile with a high grade system.
The 2 way to 3 way doesn't really make a difference in wiring but it means you'll have less power for each of the speakers. That might degrade your bass performance a little.
Power limitations depend on speakers. Are you adding an amp or just running new speakers from a stock stereo? If you're just running the stock power, you don't really need to worry about it too much. Just make sure you don't get anything that is designed for crazy amounts of power, otherwise it'll under perform it's specs.
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