Beautiful ride indeed, back in my youth (about 23 years ago, now I am 51YO) I rode my bicycle up to the skyline and did a short stint and back to the valley. No way I would try that now!
Another great ride is the Natchez Trace it goes from Natchez, MS to outside Nashville and no commercial vehicle are allowed plus the speed limit is like 50 mph. Did it on a bicycle too, only problem was finding places to get water.
Natchez Trace Parkway (U.S. National Park Service)